I roto i te umanga rongoa, ka noho a maatau hua hei waahanga matua i roto i te whakahiatotanga o te maha o nga puhui hohe koiora. Hei tauira, ko te 1-Methylimidazole he rauemi mata nui mo te whakahiato i nga takawaenga rongoa ka whakamahia ki te whakarite i nga kai rongoa kaha (API). Ko te EMI-24 me te Imidazole-4-carboxaldehyde e whakamahia nuitia ana hei takawaenga waihanga i roto i te hanga rongoa. I tua atu, ko te Prednisolone sodium phosphate he tohu anti-inflammatory me te immunosuppressive, he whai waahi nui ki te rongoa haumanu.