Dexamethasone Sodium Phosphate

Dexamethasone Sodium Phosphate is a water-soluble glucocorticoid widely used in medicine due to its potent anti-inflammatory, immunosuppressive, and anti-allergic properties. 

Applications:

1. Medical & Pharmaceutical Uses

(1) Injectable Solutions (Most Common Use)

• Emergency & Critical Care:

• Shock (Septic/Anaphylactic) – Reduces inflammation and stabilizes blood pressure.

• Cerebral Edema – Decreases brain swelling (e.g., post-stroke, tumor-related).

• Severe Allergic Reactions – Rapid-acting for asthma attacks or angioedema.

• Chemotherapy Support:

• Prevents nausea/vomiting induced by chemo/radiation.

• Reduces inflammation from tumor compression.

(2) Ophthalmic Preparations

• Eye Drops/Injections:

• Treats uveitis, allergic conjunctivitis, and post-eye surgery inflammation.

• Example: Dexamethasone Sodium Phosphate Ophthalmic Solution (0.1%).

(3) Respiratory Treatments

• Nebulized Solutions:

• Used for croup (laryngotracheobronchitis) in children.

• Combined with bronchodilators for severe asthma.

(4) Topical & Local Applications

• Ear Drops: Otitis externa/interna.

• Intra-Articular Injections: Joint inflammation (e.g., rheumatoid arthritis).

2. Veterinary Medicine

• Livestock/Pets:

• Treats inflammation, autoimmune disorders, and allergic reactions.

• Example: Canine atopic dermatitis, equine asthma.

3. Research Applications

• Cell Culture:

• Suppresses immune responses in vitro (e.g., lymphocyte studies).

• Animal Studies:

• Induces hyperglycemia or immunosuppression in lab models.