2-Acetyl Pyrazine (CAS 22047-25-2) is an organic compound with the formula C₆H₆N₂O. It is a flavor and fragrance chemical known for its strong, nutty, and popcorn-like aroma. It is widely used in the fields of food spices and pharmaceutical intermediates.
Application
1.Food Industry
As a food additive, it is commonly used in chocolate and baked goods, and is also used in corn, sesame, peanut, and beef flavorings.
2.Tobacco Industry
It is used to enhance the aroma of cigarettes and improve the quality of smoke.
3.Flavor Industry
It is an intermediate in the synthesis of many polycyclic compounds and is also used in the synthesis of flavors.
4.Pharmaceutical Industry
It is an important intermediate in the production of drugs used to treat malaria, epilepsy, and Parkinson's disease.
Synthesis Methods
Method 1
2-Acetyl pyrazine can be synthesized by dehydrating pyrazinecarboxamide to form the corresponding nitrile, which is then reacted with the Grignard reagent, methylmagnesium bromide, followed by hydrolysis.
Method 2
2-Acetyl pyrazine can also be synthesized through ester condensation reactions using ethyl pyrazine as the starting material.
Method 3
Another method involves the reaction of 2-ethylpyrazine with chlorine gas to produce 2-acetyl pyrazine.
Storage
Keep in tightly sealed containers, away from heat and light
Stable under normal conditions but may degrade with prolonged exposure to moisture
