Chlorophyllin sodium copper salt (CAS 11006-34-1) is a semi-synthetic, water-soluble derivative of chlorophyll, widely used in research, food technology, and medicine.
Food Industry Applications
Colorant: Approved in China (GB2760-1996) and internationally for candies, beverages, canned vegetables, and baked goods.
Usage Limits: Typically 0.5 g/kg; unlimited in fruit/vegetable juices.
Advantages: Superior light/heat stability compared to natural chlorophyll (half-life: 40 days)
Research and Biomedical Uses
Antioxidant & Chemopreventive Agent: Forms complexes with mutagens (e.g., heterocyclic amines) to inhibit DNA damage .
Radiation Protection: Mitigates hematopoietic syndrome in radiation-exposed models.
Wound Healing & Liver Protection: Promotes tissue repair and reduces oxidative stress in hepatocytes.
Photodynamic Therapy: Kills Staphylococcus aureus and E. coli under light exposure; used in nanogels for cancer therapy.
Drug-Detection Aid: Spectrophotometric quantification of venlafaxine hydrochloride.
Mechanisms of Action
Metal Chelation: Binds toxins via copper centers.
Immunostimulation: Enhances macrophage activity and cell proliferation.
Antimutagenicity: Inhibits carcinogens like benzopyrene, with clinical efficacy >80% for leukopenia.
