Vitamin K1 (Phytomenadione or Phylloquinone) is a natural fat-soluble vitamin sourced from green plants. It is yellow oily liquid, insoluble in water. It plays a vital role in blood clotting and bone health. This ingredient is widely used in pharmacy, nutraceuticals, functional food and cosmetics.
Key Characteristics:
Appearance: A clear, yellow to amber, viscous liquid.
Solubility: It is insoluble in water but soluble in chloroform, ether, and vegetable oils. This reflects its fat-soluble nature.
Stability: It is sensitive to light and alkalis but is stable in air.
Function: It is an essential cofactor for the synthesis of several proteins required for blood coagulation (clotting), such as prothrombin. It is also crucial for bone metabolism and vascular health.
Application:
Pharmaceutical field: Vitamin K1 serves as a critical cofactor for synthesizing hepatic blood coagulation factors. It is clinically used for prevention and treatment of vitamin K deficiency-induced hypoprothrombinemia and bleeding disorders, including hemorrhagic disease of newborns. It can reverse excessive anticoagulant effects caused by vitamin K antagonists such as warfarin, and manage bleeding risks triggered by malabsorption syndromes, long-term antibiotic therapy and liver dysfunction.
Nutraceutical and functional food sectors: it is formulated into dietary supplements, often combined with calcium and vitamin D, to support bone health by regulating osteocalcin activation and reducing the risk of bone loss.
Food fortificant: it is added to fortified beverages, dairy products and infant formula to supplement daily vitamin K intake. Its usage level is strictly regulated in all commercial applications to meet safety requirements.
Storage:
Storage in dry,cool and well-ventilated place;
Keep container tighted closed;
Keep away from heat/sparks/open flames/heat places;
Store away from incompatible material and foodstuff containers.
